Which statement best describes the administration timing of repaglinide?

Which statement best describes the administration timing of repaglinide?

• A. After meals
• B. With meals
• C. Just before meals
• D. Bedtime

Answer: (C)

Repaglinide is a rapid-acting insulin secretagogue, meaning it quickly stimulates the pancreas to release insulin in response to a meal. Because its effect is fast and short-lasting, you want it to coincide with the rise in blood glucose that comes from eating. Taking it just before meals ensures the insulin surge happens as the meal-derived glucose enters the bloodstream, optimizing post-meal glucose control. If you take it after you’ve started eating, the drug may peak too late to blunt the post-meal rise, making it less effective. Taking it at bedtime wouldn’t align with meal-related glucose and could increase the risk of hypoglycemia during fasting hours. If a meal is skipped, the dose should be skipped too.

Repaglinide is a rapid-acting insulin secretagogue, meaning it quickly stimulates the pancreas to release insulin in response to a meal. Because its effect is fast and short-lasting, you want it to coincide with the rise in blood glucose that comes from eating. Taking it just before meals ensures the insulin surge happens as the meal-derived glucose enters the bloodstream, optimizing post-meal glucose control. If you take it after you’ve started eating, the drug may peak too late to blunt the post-meal rise, making it less effective. Taking it at bedtime wouldn’t align with meal-related glucose and could increase the risk of hypoglycemia during fasting hours. If a meal is skipped, the dose should be skipped too.