Repaglinide peak concentration occurs approximately after how long?

Repaglinide peak concentration occurs approximately after how long?

• A. 15 minutes
• B. 1 hour
• C. 4 hours
• D. 8 hours

Answer: (B)

Repaglinide is a rapid-acting meglitinide secretagogue, taken before meals to trigger a quick, short-lived release of insulin in response to eating. Because it is absorbed quickly, it reaches its highest concentration in the blood about one hour after a dose. This timing matches the post-meal rise in blood glucose, helping to blunt that spike with a prompt insulin response. A peak much sooner (like 15 minutes) isn’t typical for this drug, and peaks many hours later (4 or 8 hours) wouldn’t align with the post-meal glucose rise and could miss the insulin needs during eating.

Repaglinide is a rapid-acting meglitinide secretagogue, taken before meals to trigger a quick, short-lived release of insulin in response to eating. Because it is absorbed quickly, it reaches its highest concentration in the blood about one hour after a dose. This timing matches the post-meal rise in blood glucose, helping to blunt that spike with a prompt insulin response. A peak much sooner (like 15 minutes) isn’t typical for this drug, and peaks many hours later (4 or 8 hours) wouldn’t align with the post-meal glucose rise and could miss the insulin needs during eating.